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Royal Society: Francis Crick Lecture 2016 – Dr Madan Babu Mohan on unstructured proteins


Unstructured proteins: cellular complexity and human diseases

If DNA is the blueprint of life, proteins are the building blocks. Research over the last century has shown that the shapes adopted by proteins determine their functions. Mutations that affect their shapes cause human diseases. However in recent decades, scientists have discovered that a large number of proteins do not adopt defined shapes. Nevertheless, these unstructured proteins perform functions that are critical for the survival of organisms.

In his talk Dr Mohan explores how unstructured proteins perform their functions, contribute to cellular complexity and cause human diseases including cancer and neurodegeneration.

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